APOBEC3 enzymes restrict marginal zone B cells
Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wuensche S, Walchhuetter A, Metzner M, Vettermann C, Eilat D, Defranco A, Jäck HM, Wabl M (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 45
Pages Range: 695-704
Journal Issue: 3
Abstract
In general, a long-lasting immune response to viruses is achieved when they are infectious and replication competent. In the mouse, the neutralizing antibody response to Friend murine leukemia virus is contributed by an allelic form of the enzyme Apobec3 (abbreviated A3). This is counterintuitive because A3 directly controls viremia before the onset of adaptive antiviral immune responses. It suggests that A3 also affects the antibody response directly. Here, we studied the relative size of cell populations of the adaptive immune system as a function of A3 activity. We created a transgenic mouse that expresses all seven human A3 enzymes and compared it to WT and mouse A3-deficient mice. A3 enzymes decreased the number of marginal zone B cells, but not the number of follicular B or T cells. When mouse A3 was knocked out, the retroelement hitchhiker-1 and sialyl transferases encoded by genes close to it were overexpressed three and two orders of magnitude, respectively. We suggest that A3 shifts the balance, from the fast antibody response mediated by marginal zone B cells with little affinity maturation, to a more sustained germinal center B-cell response, which drives affinity maturation and, thereby, a better neutralizing response.
Authors with CRIS profile
Rebecca Winkelmann
Department of Psychosomatic Medicine and Psychotherapy
Hans-Martin Jäck
Department of Molecular Immunology
Involved external institutions
University of California San Francisco (UCSF)
United States (USA) (US)
Philipps-Universität Marburg
Germany (DE)
Hadassah Medical Center / מרכז רפואי הדסה
Israel (IL)
United States (USA) (US)
Philipps-Universität Marburg
Germany (DE)
Hadassah Medical Center / מרכז רפואי הדסה
Israel (IL)
How to cite
APA:
Beck-Engeser, G.B., Winkelmann, R., Wheeler, M.L., Shansab, M., Yu, P., Wuensche, S.,... Wabl, M. (2015). APOBEC3 enzymes restrict marginal zone B cells. European Journal of Immunology, 45(3), 695-704. https://doi.org/10.1002/eji.201445218
MLA:
Beck-Engeser, Gabriele B., et al. "APOBEC3 enzymes restrict marginal zone B cells." European Journal of Immunology 45.3 (2015): 695-704.
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