Retinal microperfusion after renal denervation in treatment-resistant hypertensive patients
Ott C, Harazny JM, Schmid A, Ditting T, Veelken R, Bladowski M, Michelson G, Uder M, Schmieder R (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 104
Pages Range: 782-9
Journal Issue: 9
DOI: 10.1007/s00392-015-0845-0
Abstract
High pulsatile pressure and flow in the arteries causes microvascular damage, and hence increased cardio-, and cerebrovascular complications. With advanced stages of hypertensive disease, an exaggerated pulsatile retinal capillary flow (RCF) has been shown, but data about interventional effect are missing.Fifty-one patients with true treatment-resistant hypertension (TRH) underwent renal denervation (RDN) using the Symplicity Flex(TM) catheter and were followed for 12 months. RCF was assessed non-invasively using Scanning laser Doppler flowmetry (SLDF) before, 6 (6 M), and 12 (12 M) months after RDN. RCF was measured in systole and diastole and pulsed RCF (difference of RCF in systole minus diastole) was calculated. In addition, flicker light-induced vasodilation (representing vasodilatory capacity) was assessed.Systolic and diastolic office blood pressure (BP) as well as 24-h ABPM decreased significantly 6 M and 12 M after RDN, compared to baseline values (all p < 0.001). There was a significant reduction of pulsed RCF 6 M (231 ± 81 versus 208 ± 68 AU, p = 0.046) and 12 M (194 ± 72 AU, p = 0.001) after RDN, whereas the mean RCF was unchanged. Moreover, there was a significant increase of flicker light-induced vasodilation after RDN (p = 0.043).In hypertensive patients with TRH, we observed a decrease of pulsed RCF 6 M and 12 M after RDN and an increase of vasodilatory capacity, in parallel to decreases in BP and heart rate. The reduction of pulsed RCF after RDN implies a decrease of shear stress on the vascular wall by the pulsed blood flow. This and the increment of vasodilatory capacity suggest an improvement of retinal (and potentially cerebral) microcirculation.
Authors with CRIS profile
Christian Ott
Medizinische Fakultät
Roland Veelken
Medizinische Fakultät
Georg Michelson
Department of Ophthalmology
Michael Uder
Lehrstuhl für Diagnostische Radiologie
Roland Schmieder
Professur für Innere Medizin (Nephrologie)
Involved external institutions
Poland (PL)How to cite
APA:
Ott, C., Harazny, J.M., Schmid, A., Ditting, T., Veelken, R., Bladowski, M.,... Schmieder, R. (2015). Retinal microperfusion after renal denervation in treatment-resistant hypertensive patients. Clinical Research in Cardiology, 104(9), 782-9. https://doi.org/10.1007/s00392-015-0845-0
MLA:
Ott, Christian, et al. "Retinal microperfusion after renal denervation in treatment-resistant hypertensive patients." Clinical Research in Cardiology 104.9 (2015): 782-9.
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