Production of Deacetyllanatoside C by Digitalis Lanata Cell Cultures

Kreis W, Reinhard E (1990)

Publication Language: English

Publication Type: Book chapter / Article in edited volumes

Publication year: 1990

Publisher: Kluwer Academic Publishers

Edited Volumes: Progress in plant cellular and molecular biology Proceedings of the VIIth International Congress on Plant Tissue and Cell Culture, Amsterdam, The Netherlands, 24–29 June 1990

Series: Current plant science and biotechnology in agriculture

City/Town: Dordrech Boston London

Book Volume: 9

Pages Range: 706-711

ISBN: 978-94-010-7445-2

DOI: 10.1007/978-94-009-2103-0_106

Abstract

Digitalis lanata cell suspension cultures are not able to synthesize cardiac glycosides de novo but can be used to modify exogenous ones. Among the conversion reactions observed, the regio- and stereospecific 12β-hydroxylation of digitoxin derivatives to their respective digoxin derivatives is of special interest (1). In recent years, research carried out by Reinhard and co-workers focussed on a process in which β-methyldigitoxin was used as the substrate for 12β-hydroxylation. The product, β-methyldigoxin, appeared in the spent medium where levels of 500–700 mg dm−3 could be reached. A semi-continuous process for the production of β-methyldigoxin was devised and run successfully in a 300 dm3 airlift bioreactor (2).

Authors with CRIS profile

Wolfgang Kreis Lehrstuhl für Pharmazeutische Biologie

Involved external institutions

Eberhard Karls Universität Tübingen DE Germany (DE)

How to cite

APA:

Kreis, W., & Reinhard, E. (1990). Production of Deacetyllanatoside C by Digitalis Lanata Cell Cultures. In H J J Nijkamp, L H W van der Olas, J van Aatrjk (Eds.), Progress in plant cellular and molecular biology Proceedings of the VIIth International Congress on Plant Tissue and Cell Culture, Amsterdam, The Netherlands, 24–29 June 1990. (pp. 706-711). Dordrech Boston London: Kluwer Academic Publishers.

MLA:

Kreis, Wolfgang, and Ernst Reinhard. "Production of Deacetyllanatoside C by Digitalis Lanata Cell Cultures." Progress in plant cellular and molecular biology Proceedings of the VIIth International Congress on Plant Tissue and Cell Culture, Amsterdam, The Netherlands, 24–29 June 1990. Ed. H J J Nijkamp, L H W van der Olas, J van Aatrjk, Dordrech Boston London: Kluwer Academic Publishers, 1990. 706-711.

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