Ror2 signaling is required for local upregulation of GFD6 and activation of BMP signaling at the neural plate border
Schille C, Bayerlova M, Bleckmann A, Schambony A (2016)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2016
Journal
Publisher: Company of Biologists Ltd
Book Volume: 143
Pages Range: 3182-3194
Journal Issue: 17
DOI: 10.1242/dev.135426
Abstract
The receptor tyrosine kinase Ror2 is a major Wnt receptor that activates β-catenin-independent signaling and plays a conserved role in the regulation of convergent extension movements and planar cell polarity in vertebrates. Mutations in the ROR2 gene cause recessive Robinow syndrome in humans, a short-limbed dwarfism associated with craniofacial malformations. Here, we show that Ror2 is required for local upregulation of gdf6 at the neural plate border in Xenopus embryos. Ror2 morphant embryos fail to upregulate neural plate border genes and show defects in the induction of neural crest cell fate. These embryos lack the spatially restricted activation of BMP signaling at the neural plate border at early neurula stages, which is required for neural crest induction. Ror2-dependent planar cell polarity signaling is required in the dorsolateral marginal zone during gastrulation indirectly to upregulate the BMP ligand Gdf6 at the neural plate border and Gdf6 is sufficient to rescue neural plate border specification in Ror2 morphant embryos. Thereby, Ror2 links Wnt/planar cell polarity signaling to BMP signaling in neural plate border specification and neural crest induction.
Authors with CRIS profile
Carolin Schille
Lehrstuhl für Entwicklungsbiologie
Alexandra Schambony
Lehrstuhl für Entwicklungsbiologie
Involved external institutions
Germany (DE)How to cite
APA:
Schille, C., Bayerlova, M., Bleckmann, A., & Schambony, A. (2016). Ror2 signaling is required for local upregulation of GFD6 and activation of BMP signaling at the neural plate border. Development, 143(17), 3182-3194. https://doi.org/10.1242/dev.135426
MLA:
Schille, Carolin, et al. "Ror2 signaling is required for local upregulation of GFD6 and activation of BMP signaling at the neural plate border." Development 143.17 (2016): 3182-3194.
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