Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway.

Schambony A, Wedlich D (2007)


Publication Type: Journal article, Original article

Subtype: other

Publication year: 2007

Journal

Publisher: Elsevier Inc.

Book Volume: 12

Pages Range: 779-792

Journal Issue: 5

URI: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17488628&retmode=ref&cmd=prlinks

DOI: 10.1016/j.devcel.2007.02.016

Abstract

XWnt-5A, a member of the nontransforming Wnt-5A class of Wnt ligands, is required for convergent extension movements in Xenopus embryos. XWnt-5A knockdown phenocopies paraxial protocadherin (XPAPC) loss of function: involuted mesodermal cells fail to align mediolaterally, which results in aberrant movements and a selective inhibition of constriction. XWnt-5A depletion was rescued by coinjection of XPAPC RNA, indicating that XWnt-5A acts upstream of XPAPC. XWnt-5A, but not XWnt-11, stimulates XPAPC expression independent of the canonical Wnt/beta-catenin pathway. We show that transcriptional regulation of XPAPC by XWnt-5A requires the receptor tyrosine kinase Ror2. XWnt-5A/Xror2 signal through PI3 kinase and cdc42 to activate the JNK signaling cascade with the transcription factors ATF2 and c-jun. The Wnt-5A/Ror2 pathway represents an alternative, distinct branch of noncanonical Wnt signaling that controls gene expression and is required in the regulation of convergent extension movements in Xenopus gastrulation.

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How to cite

APA:

Schambony, A., & Wedlich, D. (2007). Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Developmental Cell, 12(5), 779-792. https://doi.org/10.1016/j.devcel.2007.02.016

MLA:

Schambony, Alexandra, and Doris Wedlich. "Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway." Developmental Cell 12.5 (2007): 779-792.

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