Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA.

Feike AC, Rachor K, Gentzel M, Schambony A (2010)

Publication Type: Journal article, Original article

Subtype: other

Publication year: 2010

Journal

Biochemical and Biophysical Research Communications Elsevier

Publisher: Elsevier Inc.

Book Volume: 400

Pages Range: 500-506

Journal Issue: 4

URI: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20732301&retmode=ref&cmd=prlinks

DOI: 10.1016/j.bbrc.2010.08.074

Abstract

Ror receptor-tyrosine kinases act as Wnt-5a receptors in beta-catenin independent Wnt-signaling pathways. In Xenopus, expression of xPAPC is regulated by a Wnt-5a/Ror2 pathway, which resembles typical signaling cascades downstream of receptor-tyrosine kinases. Here, we have identified the phospho-tyrosine binding protein ShcA as an intracellular binding partner of Ror2. ShcA binds to a conserved motif in Ror2 via its SH2-domain. Wnt-5a induces clustering of Ror2 in the cell membrane and recruitment of ShcA to the Ror2 receptor complex. We further show that ShcA is co-expressed with Ror2 in developing Xenopus embryos and ShcA is required for Wnt-5a/Ror2 mediated upregulation of xPAPC, demonstrating the functional relevance of this interaction.

Authors with CRIS profile

Alexandra Schambony Lehrstuhl für Entwicklungsbiologie

Involved external institutions

Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) DE Germany (DE)

How to cite

APA:

Feike, A.C., Rachor, K., Gentzel, M., & Schambony, A. (2010). Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA. Biochemical and Biophysical Research Communications, 400(4), 500-506. https://doi.org/10.1016/j.bbrc.2010.08.074

MLA:

Feike, Ann Caroline, et al. "Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA." Biochemical and Biophysical Research Communications 400.4 (2010): 500-506.

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