Hammon M, Großmann S, Linz P, Kopp C, Dahlmann A, Garlichs C, Janka RM, Luft FC, Uder M, Titze J, Cavallaro AJ (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 10
Pages Range: e0141336
Journal Issue: 10
DOI: 10.1371/journal.pone.0141336
Na+ can be stored in muscle and skin without commensurate water accumulation. The aim of this study was to assess Na+ and H2O in muscle and skin with MRI in acute heart failure patients before and after diuretic treatment and in a healthy cohort.Nine patients (mean age 78 years; range 58-87) and nine age and gender-matched controls were studied. They underwent 23Na/1H-MRI at the calf with a custom-made knee coil. Patients were studied before and after diuretic therapy. 23Na-MRI gray-scale measurements of Na+-phantoms served to quantify Na+-concentrations. A fat-suppressed inversion recovery sequence was used to quantify H2O content.Plasma Na+-levels did not change during therapy. Mean Na+-concentrations in muscle and skin decreased after furosemide therapy (before therapy: 30.7±6.4 and 43.5±14.5 mmol/L; after therapy: 24.2±6.1 and 32.2±12.0 mmol/L; p?0.05 and p?0.01). Water content measurements did not differ significantly before and after furosemide therapy in muscle (p = 0.17) and only tended to be reduced in skin (p = 0.06). Na+-concentrations in calf muscle and skin of patients before and after diuretic therapy were significantly higher than in healthy subjects (18.3±2.5 and 21.1±2.3 mmol/L).23Na-MRI shows accumulation of Na+ in muscle and skin in patients with acute heart failure. Diuretic treatment can mobilize this Na+-deposition; however, contrary to expectations, water and Na+-mobilization are poorly correlated.
APA:
Hammon, M., Großmann, S., Linz, P., Kopp, C., Dahlmann, A., Garlichs, C.,... Cavallaro, A.J. (2015). 23Na Magnetic Resonance Imaging of the Lower Leg of Acute Heart Failure Patients during Diuretic Treatment. PLoS ONE, 10(10), e0141336. https://doi.org/10.1371/journal.pone.0141336
MLA:
Hammon, Matthias, et al. "23Na Magnetic Resonance Imaging of the Lower Leg of Acute Heart Failure Patients during Diuretic Treatment." PLoS ONE 10.10 (2015): e0141336.
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