Nimmerjahn F (2008)
Publication Status: Published
Publication Type: Journal article
Publication year: 2008
Book Volume: 415
Pages Range: 151-62
DOI: 10.1007/978-1-59745-570-1_9
Cellular receptors for immunoglobulins (Fc-receptors; FcR) are central mediators of antibody-triggered effector functions. Immune complex (IC) binding to FcRs results in a variety of reactions such as the release of inflammatory mediators, antibody dependent cellular cytotoxicity (ADCC) and phagocytosis of ICs. Analyzing antibody-FcR (Ab-FcR) interactions in vitro is essential to determine the effector mechanisms, binding characteristics and affinity parameters that will impact and predict antibody activity in vivo. The methods described in this chapter include the generation of ICs and soluble FcR variants, as well as ELISA and FACS-based assays to study Ab-FcR interactions.
APA:
Nimmerjahn, F. (2008). Analyzing antibody-Fc-receptor interactions. Methods in Molecular Biology, 415, 151-62. https://doi.org/10.1007/978-1-59745-570-1_9
MLA:
Nimmerjahn, Falk. "Analyzing antibody-Fc-receptor interactions." Methods in Molecular Biology 415 (2008): 151-62.
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