KRAS, EGFR, PDGFR-?, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE)
Veits L, Schupfner R, Hufnagel P, Penzel R, Freitag J, Stroebel P, Kern MA, Schroeder S, Neuhold N, Schmid KW, Schirmacher P, Hartmann A, Rieker RJ (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 9
Pages Range: 116
Abstract
CASTLE (Carcinoma showing thymus-like elements) is a rare malignant neoplasm of the thyroid resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus with different biological behaviour and a better prognosis than anaplastic carcinoma of the thyroid.We retrospectively investigated 6 cases of this very rare neoplasm in order to investigate the mutational status of KRAS, EGFR, PDGFR-? and KIT, as well as the immunohistochemical expression pattern of CD117, EGFR and COX-2, and possibly find new therapeutic targets.Diagnosis was confirmed by a moderate to strong expression of CD5, CD117 and CK5/6, whereas thyroglobulin, calcitonin and TTF-1 were negative in all cases. Tumors were also positive for COX-2 and in nearly all cases for EGFR. In four cases single nucleotide polymorphisms (SNPs) could be detected in exon 12 of the PDGFR-? gene (rs1873778), in three cases SNPs were found in exon 20 of the EGFR gene (rs1050171). No mutations were found in the KIT and KRAS gene.All tumors showed a COX-2 expression as well as an EGFR expression except for one case and a wild-type KRAS status. No activating mutations in the EGFR, KIT and PDGFR-? gene could be detected. Our data may indicate a potential for targeted therapies, but if these therapeutic strategies are of benefit in CASTLE remains to be determined.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1658499296115016.
Authors with CRIS profile
Involved external institutions
Klinikum Bayreuth
Germany (DE)
Pathologielabor Zams
Austria (AT)
Skåne University Hospital / Skånes universitetssjukhus
Sweden (SE)
Labor Lademannbogen
Germany (DE)
Universitätsklinikum Essen
Germany (DE)
Germany (DE)
Pathologielabor Zams
Austria (AT)
Skåne University Hospital / Skånes universitetssjukhus
Sweden (SE)
Labor Lademannbogen
Germany (DE)
Universitätsklinikum Essen
Germany (DE)
How to cite
APA:
Veits, L., Schupfner, R., Hufnagel, P., Penzel, R., Freitag, J., Stroebel, P.,... Rieker, R.J. (2014). KRAS, EGFR, PDGFR-?, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE). Diagnostic Pathology, 9, 116. https://doi.org/10.1186/1746-1596-9-116
MLA:
Veits, Lothar, et al. "KRAS, EGFR, PDGFR-?, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE)." Diagnostic Pathology 9 (2014): 116.
BibTeX: Download