Kinetic Study of the Asymmetric Hydrogenation of Methyl Acetoacetate in the Presence of a Ruthenium Binaphthophosphepine Complex
Öchsner E, Etzold B, Junge K, Beller M, Wasserscheid P (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Publisher: Wiley-VCH Verlag
Book Volume: 351
Pages Range: 235--245
Volume: 351
Issue: 1-2
Journal Issue: 1-2
Abstract
The asymmetric hydrogenation of methyl acetoacetate (MAA) in methanol using dibromobis(S)-4-phenyl-4,5-dihydro-3H-dinaphtho[2,1-c: 1$\prime$,2$\prime$-e]phosphepine-ruthenium was studied in detail. For the determination of the reaction network, data from kinetic experiments were compared to different possible reaction networks using the kinetic software Presto Kinetics. The simulation was optimised to describe the reaction accurately with a minimal set of process parameters and reaction equations. For the best model the reaction orders, collision factors and activation energy of all reaction steps were determined. Additionally, the influence of reaction temperature and hydrogen pressure on the enantiomeric excess (ee) of the reaction was studied. It was found that high reaction temperatures and high hydrogen pressures result in increasing enantioselectivities.
Authors with CRIS profile
Bastian Etzold
Professur für Katalytische Materialien
Peter Wasserscheid
Lehrstuhl für Chemische Reaktionstechnik (CRT)
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Öchsner, E., Etzold, B., Junge, K., Beller, M., & Wasserscheid, P. (2009). Kinetic Study of the Asymmetric Hydrogenation of Methyl Acetoacetate in the Presence of a Ruthenium Binaphthophosphepine Complex. Advanced Synthesis & Catalysis, 351(1-2), 235--245. https://doi.org/10.1002/adsc.200800531
MLA:
Öchsner, Eva, et al. "Kinetic Study of the Asymmetric Hydrogenation of Methyl Acetoacetate in the Presence of a Ruthenium Binaphthophosphepine Complex." Advanced Synthesis & Catalysis 351.1-2 (2009): 235--245.
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