Biburger M, Theiner G, Schädle M, Schuler G, Tiegs G (2010)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2010
Publisher: Society for Leukocyte Biology
Book Volume: 87
Pages Range: 193-202
Journal Issue: 2
DOI: 10.1189/jlb.0508280
HO-1 is the only inducible one of three isoenzymes that catalyzes the oxidative degradation of heme. HO-1 is inducible by various cellular stress factors and exerts cytoprotective and immunomodulatory effects. Recent publications demonstrated that HO-1 is constitutively expressed by CD4 CD25 T and induced in CD4 CD25 T cells upon FoxP3 transfection. Here, we investigated whether HO-1 was essential and sufficient for human T to exert immunosuppression in vitro. PGJ induced pronounced expression of HO-1 in CD4CD25 T cells without accompanying FoxP3 induction. Treatment of CD4CD25 T cells with PGJ decreased their proliferation, whereas the HO-1 inhibitor SnPP enhanced the proliferation of HO-1-expressing T, suggesting that HO-1 may modulate the proliferative capacity of T lymphocytes. HO-1 modulation by SnPP treatment of T or PGJ treatment of CD4CD25 T cells neither suppressed nor induced immune-modulatory function in these cells, respectively, as measured by responder-cell proliferation and/or IL-2 production. In summary, these data suggest that HO-1 expression by T might contribute to their typical reluctance to proliferate but does not account independently for their suppressive functions. © Society for Leukocyte Biology.
APA:
Biburger, M., Theiner, G., Schädle, M., Schuler, G., & Tiegs, G. (2010). Pivotal advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity. Journal of Leukocyte Biology, 87(2), 193-202. https://doi.org/10.1189/jlb.0508280
MLA:
Biburger, Markus, et al. "Pivotal advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity." Journal of Leukocyte Biology 87.2 (2010): 193-202.
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