Role of "Western diet" in inflammatory autoimmune diseases

Manzel A, Muller DN, Hafler DA, Erdman SE, Linker R, Kleinewietfeld M (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Current Allergy and Asthma Reports Current Medicine Group

Publisher: Current Medicine Group

Book Volume: 14

Pages Range: 404

Journal Issue: 1

DOI: 10.1007/s11882-013-0404-6

Abstract

Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the "Western diet", including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and 'fast foods', promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. Underlying metabolic and immunologic mechanisms are currently being intensively explored. This review discusses the current knowledge relative to the association of "Western diet" with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology.

Authors with CRIS profile

Ralf Linker Department of Neurology

Involved external institutions

Experimental and Clinical Research Center (ECRC) DE Germany (DE) Yale University US United States (USA) (US) Massachusetts Institute of Technology (MIT) US United States (USA) (US)

How to cite

APA:

Manzel, A., Muller, D.N., Hafler, D.A., Erdman, S.E., Linker, R., & Kleinewietfeld, M. (2014). Role of "Western diet" in inflammatory autoimmune diseases. Current Allergy and Asthma Reports, 14(1), 404. https://doi.org/10.1007/s11882-013-0404-6

MLA:

Manzel, Arndt, et al. "Role of "Western diet" in inflammatory autoimmune diseases." Current Allergy and Asthma Reports 14.1 (2014): 404.

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