Hydration mechanism of partially amorphized β-tricalcium phosphate

Hurle K, Neubauer J, Götz-Neunhoeffer F (2017)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2017


Publisher: Elsevier Ltd

Book Volume: 54

Pages Range: 429-440

DOI: 10.1016/j.actbio.2017.03.013


Calcium phosphate cements (CPCs) are applied as bone cements due to their excellent biocompatibility. In the present study, the quantitative phase content development during hydration of partially amorphized β-tricalcium phosphate (β-TCP) within the first 24 h was investigated by in-situ X-ray diffraction (XRD) combined with the G-factor method, an external standard method. The quantity of amorphous phase (ATCP) in the powders was determined by the G-factor method.

The hydration model established for partially amorphized β-TCP indicates that ATCP reacted first, followed by the hydration of a small fraction of crystalline β-TCP starting after some h. Consequently, hydration resulted in biphasic samples composed of calcium deficient hydroxyapatite (CDHA) and crystalline β-TCP. The ratio wt%(CDHA)/wt%(β-TCP) after 24 h hydration was adjustable by the initial ATCP content. The crystallinity of CDHA was nearly independent of the ATCP content. Since the biological degradability of CDHA and β-TCP differ, the degradation performance of the set cements is expected to be adjustable by varying the ATCP content. The present study provided a basic understanding of the hydration mechanism of partially amorphized β-TCP, which is the prerequisite for the development of applicable CPC formulations.

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Hurle, K., Neubauer, J., & Götz-Neunhoeffer, F. (2017). Hydration mechanism of partially amorphized β-tricalcium phosphate. Acta Biomaterialia, 54, 429-440. https://doi.org/10.1016/j.actbio.2017.03.013


Hurle, Katrin, Jürgen Neubauer, and Friedlinde Götz-Neunhoeffer. "Hydration mechanism of partially amorphized β-tricalcium phosphate." Acta Biomaterialia 54 (2017): 429-440.

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