Missing in action-The meaning of cell death in tissue damage and inflammation

Munoz Becerra L, Leppkes M, Fuchs TA, Hoffmann M, Herrmann M (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Immunological Reviews Wiley-Blackwell

Book Volume: 280

Pages Range: 26-40

Journal Issue: 1

DOI: 10.1111/imr.12569

Abstract

Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Neutrophils are the most abundant effector immune cells that extravasate into tissues and can turn injured tissues into gory battle fields. In peace times, neutrophils tend to patrol tissues without provoking inflammatory reactions. We discuss in this review actual and forgotten knowledge about the meaning of cell death during homeostatic processes and drive the attention to the importance of the action of neutrophils during patrolling and for the maintenance or recovery of the homeostatic state once the organism gets attacked or injured, respectively. In this fashion, we disclose several disease conditions that arise as collateral damage of physiological responses to death.

Authors with CRIS profile

Luis Munoz Becerra Department of Medicine 3 – Rheumatology and Immunology Markus Hoffmann Department of Medicine 3 – Rheumatology and Immunology Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE)

How to cite

APA:

Munoz Becerra, L., Leppkes, M., Fuchs, T.A., Hoffmann, M., & Herrmann, M. (2017). Missing in action-The meaning of cell death in tissue damage and inflammation. Immunological Reviews, 280(1), 26-40. https://doi.org/10.1111/imr.12569

MLA:

Munoz Becerra, Luis, et al. "Missing in action-The meaning of cell death in tissue damage and inflammation." Immunological Reviews 280.1 (2017): 26-40.

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