A106: Evaluating RIP kinases as novel regulators of salivary gland homeostasis and Sjögren Syndrom-like pathology
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.02.2026
End date : 15.08.2028
Project details
Scientific Abstract
Primary Sjögrens syndrome (PSS) is an autoimmune disease causing chronic inflammation of exocrine glands, dry mouth and eyes. Our preliminary data identify RIP kinases as novel regulators of salivary gland homeostasis and potential factors in PSS. Inducible RIP kinase-deficient mice develop PSS-like disease and implicate this kinase in immune regulation and epithelial homeostasis within the salivary gland. This proposal aims to clarify the role of RIP kinases in the salivary gland and in PSS.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
