E41: Mechanisms of axon length-dependent synapse vulnerability in neurodegeneration
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.05.2026
End date : 31.10.2028
Project details
Scientific Abstract
Neurodegenerative disorders (NDs) frequently affect complex neurons with long axons. We hypothesize that axon length represents a molecularly defined source of intrinsic vulnerability to synapse loss, an early pathological feature of many NDs. We aim to identify these molecular signals, assay multiple ND-linked models and validate drivers of axon length-dependent synapse loss in human cells to provide insight into conserved molecular mechanisms as an entry point for early treatment of NDs.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Professur für Zelluläre und Molekulare Neurophysiologie
