E38: Investigating the role of mitotic functions of SOX11 in the pathogenesis of neurodevelopmental disorders
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.03.2026
End date : 31.08.2028
Project details
Scientific Abstract
Heterozygous variants in the transcription factor SOX11 have been linked to a rare neurodevelopmental syndrome featuring intellectual disability and microcephaly. This project investigates the novel concept that SOX11 plays an essential role for mitotic spindle function through a non-transcriptional mechanism and that disruption of this mechanism contributes to the pathogenesis of SOX11-linked neurodevelopmental disorders.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Mikroskopische Anatomie und Molekulare Bildgebung
