P188_OA: Allospecific Responses of Marginal Zone B Cells in Kidney Transplantation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.03.2026
End date : 28.02.2027
Project details
Scientific Abstract
Rejection is a major cause of allograft failure. The role of marginal zone B cells in kidney transplantation is unkown. In this project, we will investigate the donor-specific responses of marginal zone B cells using a rat kidney transplantat model. Specifically, we will determine the capacity of marginal zone B cells to produce anti-donor antibodies, to secrete inflammatory or regulatory cytokines and the sensitivity towards anti-BAFF antibody treatment in a kidney transplant model.
