IZKF-ER Stress und Sialylierung in Plasm: The role of endoplasmic reticulum (ER) stress and surface sialylation in regulating plasma cell fate
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2026
End date : 31.07.2028
Project details
Scientific Abstract
We found in mice and humans a plasma cell population with high surface sialylation. We hypothesize that this population represents activated plasma cells that experience ER stress and await survival signals. We will characterize these cells in mice and humans regarding ER stress, survival, signalling and metabolism, analyse plasma cells from mice with B cell intrinsic elevated ER stress, investigate niche support and how surface sialylation influences plasmablast/ plasma cell fate.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
