FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2026
End date : 30.06.2028
Intestinal B cells, including plasmablasts are potentially involved in the pathogenesis of ulcerative colitis (UC), as their elevated mucosal presence has recently been described in resistant disease courses. Based on own findings of a successful CD19 CAR T cell treatment in a patient with refractory UC, we aim to characterize the role of gut B cells in perpetuating the inflammatory process and to understand the therapeutic potential of depleting specific B cell subsets in UC.