A105: Volume-Regulated Anion Channel (VRAC) as a regulator of T cell immunometabolism and intestinal inflammation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2026
End date : 30.06.2028
Project details
Scientific Abstract
We will define the relevance of VRAC for T cell function in colitis and validate VRAC as a potential target for IBD therapy. Our initial data point to a functional role of VRAC in T cell-driven colitis and implicate that VRAC modulates immunometabolism and mechanical properties of T cells. Using VRAC KO mice and IBD tissue samples, we will elucidate the colitis-regulating capacity of VRAC in T cells, identify modulators of VRAC expression and define its interplay with T cell immunometabolism.
