P164: Define the role of Annexins as ligands of Dectin-1 regulating osteoclast differentiation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.05.2025
End date : 30.04.2026
Project details
Scientific Abstract
Our preliminary results suggest that AnnexinA1, which is expressed by dying cells within the bone marrow niche, will bind to Dectin-1 on osteoclasts to induce osteoclast differentiation and bone resorption in non-inflammatory conditions. Therefore, I will analyse the molecular mechanism of AnnexinA1 induced Dectin-1 signaling. Furthermore, I aim to define the AnnexinA1 expressing myeloid cell population within the bone marrow niche and its impact on osteoclast differentiation.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
