FAU own research funding: EFI / IZKF / EAM ...
Start date : 15.09.2025
End date : 14.09.2026
In this project, the role of the AP-1 transcription factor Fos-like 2 (FOSL2) in tumor dormancy of malignant melanoma is investigated. Based on a 3D biofabricated dormancy model, preliminary work has shown that FOSL2 is highly expressed in dormant melanoma cells and that its downregulation prevents the formation of dormancy in these cells. The influence of extracellular factors on FOSL2 and potential target genes are being investigated in the 3D printed system.