Third Party Funds Group - Sub project
Acronym: GRK 2950 P5
Start date : 01.06.2024
End date : 31.05.2029
Website: https://www.symocads.research.fau.eu/
The goal of this project is to establish MC-based models and algorithms for optimization of SPION steering systems in highly branched vascular and tissue structures. To this end, a comprehensive numerical model for the MC channel relevant for SPION steering will be derived. Furthermore, in order to enable efficient optimization of the SPION steering system at affordable computational cost, a lumped-parameter approach will be used to develop approximate models. Based on these approximate models, given a certain vessel topology and tissue structure, algorithms for maximization of the number of particles delivered to a target area (representing the MC receiver) will be investigated, where both static and dynamic (time-varying) steering systems will be considered. The findings of P4 regarding the forces relevant for SPION steering will be integrated for development of the proposed comprehensive and approximate MC channel models as they become available. Furthermore, besides conventional electromagnets, the linear array structures investigated in P4 will be considered for steering algorithm design. Moreover, the developed MC channel models and steering algorithms will be experimentally validated and refined exploiting the physical tumor models provided by P6.