Impact of vascular plasticity on therapy responses in CRC (P06) (SFB/TRR 417 P06)

Third Party Funds Group - Sub project


Acronym: SFB/TRR 417 P06

Start date : 01.10.2025

End date : 30.06.2029

Overall project details

Overall project

TRR 417: Zelluläre Kommunikation im Stroma von kolorektalen Karzinomen: von der Pathophysiologie bis zur klinischen Translation

Project details

Scientific Abstract

The matricellular protein SPARCL1 which is expressed preferentially in tumor vessel endothelial cells (TEC) of CRCs with a Th1-like TME, acts as angiocrine repressor of tumorigenesis by stabilizing vessels, inhibiting angiogenesis and tumor cell proliferation. Employing a vessel-specific knockout of SPARCL1 (SPARCL1ΔIECKO). The project will determine the impact of TEC plasticity on lipid metabolism and ferroptosis and their role for therapy response, including standard chemotherapy, targeted therapy or immunotherapy and elucidate the molecular mechanisms involved.

Involved:

Claudia Günther Project Leader Elisabeth Naschberger Project Leader

Contributing FAU Organisations:

Department of Surgery Professur für Gastrointestinale Pathophysiologie

Funding Source

DFG / Sonderforschungsbereich / Transregio (SFB / TRR)