P175: Neonatal organoids to understand the impact of bacterial metabolites during gut maturation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.04.2025
End date : 31.03.2026
Project details
Scientific Abstract
The project aims to explore differences in how neonatal and adult intestinal epithelial cells respond to microbial metabolites. As the first line of immune defense, epithelial cells regulate the balance between tolerance and immune responses. The impact of bacterial colonization on gut maturation is poorly understood but may shape future immune responses. This study will shed light on how early-life events influence immune development and their role in autoimmune diseases like IBD, MS, and SLE.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
