P158: CSF1R-interactome analysis to identify signaling modulators in HDLS
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2025
End date : 31.12.2025
Project details
Scientific Abstract
Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a fatal adult-onset neurological disease caused by pathological variants in CSF1R (colony-stimulating factor-1 receptor). As microglia are primarily affected in HDLS, we developed an iPSC-derived microglia model to study CSF1R function in healthy and HDLS patient lines. Using this model, we propose to investigate novel CSF1R interactions using APEX2-based proximity labeling focusing on transcriptional regulation.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Professur für Stammzell-Modelle seltener neuraler Erkrankungen
