J114: Profiling of transcriptional regulatory circuitries in the development of clear cell renal cell carcinoma
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.08.2024
End date : 31.01.2027
Project details
Scientific Abstract
A comprehensive molecular characterization of transcription factor dynamics in ccRCC evolution is a mandatory prerequisite for the development of personalized therapeutic interventions. Aim of this study is to define the components and interactions of oncogenic regulatory circuitries in ccRCC development with innovative NGS techniques. CRISPR/Cas-modified cell lines and patient-derived primary cells will be used to model early tumor stages and analyse epigenetic dysregulation in ccRCC evolution.
Involved:
Stephanie Naas
Project Leader
Pooja Gupta
Project Member
Arndt Hartmann
Project Member
Bernd Wullich
Project Member
Björn Buchholz
Project Member
Contributing FAU Organisations:
Medizinisches Zentrum für Informations- und Kommunikationstechnik (Medizinisches IK-Zentrum, MIK)
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Urologie
Department of Medicine 4 – Nephrology and Hypertension
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
