P157: Characterization of neoantigen-directed T-cell receptor-based cell therapies in a 3D breast cancer model
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.11.2024
End date : 31.10.2025
Project details
Scientific Abstract
In breast cancer, the success of neoadjuvant chemotherapy depends on tumor-infiltrating lymphocytes and their specificity, especially against neoantigens - promising targets for immunotherapies. 3D-cell cultures offer a more realistic representation of tumor-immune cell interactions than conventional ones. The project seeks to compare 4 T-cell receptor-based immunotherapies against neoantigens in 2D- and 3D-models, aiming to identify the most promising approach for potential future treatments.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 5 – Haematology and Oncology
