IZKF-N9 Engineered cells skin dis(601/DE: Dressing up and ready to move: Engineered immune cells for treatment of autoimmune skin diseases
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2024
End date : 30.06.2026
Extension date: 30.06.2027
Project details
Scientific Abstract
We hypothesize that, during inflammation, a highly motile subset of lymphocytes, including T cells, B cells and regulatory T cells migrate from the blood into the skin. An in-depth characterization of this highly motile skin-reaching subset would allow us to identify the select molecules employed by these cells to migrate into the skin and to mediate T cell suppression. We propose that we can engineere blood-derived immune cells with these molecules to unleash their migratory and functional behavior and, as a consequence, their therapeutic potential to dampen the symptoms associated with inflammatory skin disease.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Dermatology
Medizinische Fakultät
Professur für Translationale Immundermatologie
