Renal ENaC regulation by the transmembrane serine protease TMPRSS2 and structure-based analysis of proteolytic channel activation (A04) (SFB/TRR 374 A04)

Third Party Funds Group - Sub project


Acronym: SFB/TRR 374 A04

Start date : 01.01.2023

End date : 31.12.2026

Overall project details

Overall project

TRR 374: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk

Project details

Short description

Recently, we identified TMPRSS2 as novel candidate protease to activate the epithelial sodium channel (ENaC) by proteolytic cleavage. We aim to elucidate the role of TMPRSS2 in renal ENaC regulation and gain further insights into the complex molecular mechanisms of proteolytic and non-proteolytic ENaC activation. A better understanding of ENaC function at the molecular level may lead to novel (patho-) physiological and therapeutic concepts for renal disorders involving increased ENaC activity and renal salt retention.

Scientific Abstract

Recently, we identified TMPRSS2 as novel candidate protease to activate the epithelial sodium channel (ENaC) by proteolytic cleavage. We aim to elucidate the role of TMPRSS2 in renal ENaC regulation and gain further insights into the complex molecular mechanisms of proteolytic and non-proteolytic ENaC activation. A better understanding of ENaC function at the molecular level may lead to novel (patho-) physiological and therapeutic concepts for renal disorders involving increased ENaC activity and renal salt retention.

Involved:

Alexandr Ilyaskin Project Leader Christoph Korbmacher Project Leader

Contributing FAU Organisations:

Lehrstuhl für Physiologie (Vegetative Physiologie)

Funding Source

DFG / Sonderforschungsbereich / Transregio (SFB / TRR)