E034: How neural stem cells shape their regulatory environment in the adult CNS

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.07.2023

End date : 30.11.2025

Extension date: 31.03.2026

Project details

Scientific Abstract

An adverse local environment ("niche") impairs the activity of neural stem cells (NSCs) in the adult brain. We investigate the new hypothesis that NSCs play an active role in generating favorable and adverse niche conditions. Specifically, we will investigate how dysfunctional NSCs generate adverse niche conditions focusing i) on the composition and the biomechanical properties of the extracellular matrix and ii) on NSC-derived exosomes and their composition.

Involved:

Kristian Franze Project Leader Dieter Chichung Lie Project Leader Julio Vera González Project Member

Contributing FAU Organisations:

Professur für Tumorimmunologie (Schwerpunkt Systembiologie) Professur für Molekulare Medizin mit dem Schwerpunkt Molekulare Bildgebung Lehrstuhl für Medizinische Physik und Mikrogewebetechnik (IMP)

Funding Source

Mittelgeber / Förderprogramme