A099: Deciphering the mechanisms of cortical bone remodelling and its impact on bone quality
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2023
End date : 31.12.2025
Project details
Scientific Abstract
Constant bone remodelling is important to prevent fractures. In bones with a thick cortex, we found that remodelling is based on endosteal bone formation and periosteal resorption which stands in contrast to existing models. In this project we will characterize this process and analyse its dependence on age, mechanical load, osteoclast and osteocyte activity. We aim to explain why some bone sites are prone to fracture and to develop new treatment strategies to prevent insufficiency fracture.
Involved:
Ulrike Steffen
Project Leader
Andreas Ramming
Project Member
Aline Bozec
Project Member
Martin Schicht
Project Member
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Professur für Experimentelle Immuntherapie
Lehrstuhl für Funktionelle und Klinische Anatomie
Lehrstuhl für Innere Medizin III
Medizinische Fakultät
