A102: Mechanical properties of innate immune cells: functional relevance and therapeutic implications in colitis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2023
End date : 31.12.2025
Project details
Scientific Abstract
Immune cell trafficking plays a central role in the pathogenesis of ulcerative colitis (UC). Based on our preliminary data, we propose cell mechanics as an important mechanism in this process. To explore this hypothesis, we will investigate mechanisms regulating mechanics of innate immune cells in colitis models. We will further explore the functional consequences of immune cell deformability in acute colitis and explore therapeutic opportunities for a modulation of cell mechanics in UC.
Involved:
Jochen Guck
Project Leader
Maximilian Waldner
Project Leader
Sebastian Zundler
Project Member
Moritz Leppkes
Project Member
Contributing FAU Organisations:
Lehrstuhl für Biologische Optomechanik
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Professur für Funktionelle Bildgebung in der Medizin
Medizinische Fakultät
