D038: Impact of the transcriptional regulator AP2e on melanoma development and progression
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.03.2023
End date : 15.09.2025
Project details
Scientific Abstract
The transcription factor family AP2 has important functions in development. AP2e was discovered in cooperation with this PI. We newly observed delayed onset of tumorigenesis in a murine Ap2e-deficient melanoma model. This is supported by expression data showing induced AP2e mRNA expression in early tumor development and a correlation of high Ap2e expression with reduced overall survival. In the project, the role of Ap2e in development and progression of melanoma is explored in molecular detail.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Biochemie und Molekulare Medizin
Medizinische Fakultät
