D041: Ferroptosis and phospholipid metabolism for chemo- and immunotherapy sensitization in urothelial cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2023
End date : 31.12.2025
Project details
Scientific Abstract
Urothelial carcinoma (UC) is among the ten most common cancers worldwide and overall therapy systemic response rates are limited (~20%). Molecular insights in processes driving therapy resistance are scarce. Here, we propose to expand our existing patient-derived living UC biobank, develop a novel zebrafish model to study the role of fatty acid metabolism and ferroptosis in UC, and to determine if the zebrafish allows the pre-selection of therapy responsive patients.
Involved:
Contributing FAU Organisations:
Institute of Pathology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Nephropathology
Medizinische Fakultät
