P124: Modulation of store operated calcium entry in hereditary spastic paraplegia using Davunetide
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.04.2023
End date : 15.06.2023
Project details
Scientific Abstract
Pathogenic variants in SPAST, which encodes spastin, a microtubule-severing enzyme, are the most common cause of Hereditary spastic paraplegia, a motor neuron disorder affecting the axons of corticospinal motor neurons. To date, therapeutic strategies focus on ameliorating the symptoms without treating the underlying cause. Here we investigate the effects of microtubule modifying drugs on SPAST induced pluripotent stem cell derived neurons.
Involved:
Contributing FAU Organisations:
Professur für Stammzell-Modelle seltener neuraler Erkrankungen
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
