P116: The role of Butyrophilin 2a2 (Btn2a2) in T cell maturation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2022
End date : 30.09.2023
Project details
Scientific Abstract
Btn2a2 inhibits T cell activation in vitro and Btn2a2-/- mice show exacerbated experimental autoimmune encephalomyelitis, suggesting a T cell inhibitory role. Strikingly, Btn2a2-/- mice exhibit elevated autoantibody titers, suggesting a defect in tolerance mechanisms. We hypothesize that Btn2a2 affects thymocytes during thymocyte selection, resulting in an altered autoaggressive T cell repertoire.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
