J102: The role of cDC1s in abscopal effects of a multimodal radioimmunotherapy including whole tumor cell vaccines
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.12.2022
End date : 31.05.2025
Project details
Scientific Abstract
Abscopal effects are rare events of local radiotherapy (RT) inducing systemic anti-tumor immune responses leading to the reduction of tumor masses outside of the irradiation field. We hypothesize that the addition of adjuvants to high hydrostatic pressure generated whole tumor cell vaccines in combination with RT and immune checkpoint inhibition induce abscopal effects in an orthotopic breast cancer model. Further, we hypothesize that cDC1s play a central role in this immune response.
Involved:
Michael Rückert
Project Leader
Markus Eckstein
Project Member
Diana Dudziak
Project Member
Eberhard Schlücker
Project Member
Stefan Uderhardt
Project Member
Christoph Bert
Project Member
Arif Bülent Ekici
Project Member
Contributing FAU Organisations:
Professur für Med. Strahlenphysik
Lehrstuhl für Prozessmaschinen und Anlagentechnik (iPAT)
Institute of Pathology
Professur für die Biologie Dendritischer Zellen
Institute of Human Genetics
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Department of Radiation Oncology
Medizinische Fakultät
