A7: Characterization and mathematical modeling of the STAT6-regulated micromilieu in response to Nippostrongylus brasiliensis infections (GRK 2740 ImmunoMicroTope Project A7)

Third Party Funds Group - Sub project


Acronym: GRK 2740 ImmunoMicroTope Project A7

Start date : 01.01.2022

End date : 30.06.2026

Website: https://www.immunomicrotope.de/beispiel-seite/project-areas/project-area-a-micro-milieu/a7-characterization-and-mathematical-mod

Overall project details

Overall project

GRK 2740: Immunmikrotop: Mikroumgebungsbedingte, metabolische und mikrobielle Signale zur Regulation der Immunzell-Pathogen-Interaktion

Project details

Scientific Abstract

Helminth infections affect about 1/3 of the world population and to date there are no helminth-specific vaccines available. IL-4/IL-13-induced activation of the transcription factor STAT6 in non-hematopoetic cells plays a critical role for worm expulsion during infection with gastrointestinal helminths. We will investigate how expression of STAT6-regulated genes in different cell types cause changes of the immunomicrotope (mucus production, pH, tissue tonicity, short chained fatty acids) in skin, lung and intestine. We will further determine how the worm transcriptome changes during colonization of the small intestine in wild-type versus STAT6-deficient mice. In close collaboration with Vasily Zaburdaev (part B of this project) we will use mathematical modeling to address changes of individual parameters on tissue migration and expulsion of N. brasiliensis.

Involved:

Vasily Zaburdaev Project Leader David Vöhringer Project Leader

Contributing FAU Organisations:

Professur für Infektionsabwehr und Toleranz Lehrstuhl für Mathematik in den Lebenswissenschaften

Funding Source

DFG / Graduiertenkolleg (GRK)