P098: Acetate inhibits T cell dependent humoral immune responses by reducing T cell migration and motility
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.04.2022
End date : 31.07.2022
Project details
Scientific Abstract
Epidemiological studies showed that alcohol intake reduces the incidence of RA. We published that alcohol sourced acetate prevents Tfh:B cell conjugates, crucial for antibody secretion. Here, we provide data showing that acetylation of cytoskeletal proteins by acetate reduces T cell motility. We propose to study if increased acetate levels favor cytoskeletal protein acetylation impacting cell motility and migration with direct consequences on the onset of autoimmunity and vaccination efficacies.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
