J086: Interplay between the gut virome and mucosal macrophages in determining anti-TNF resistance in Crohns disease
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2021
End date : 30.06.2022
Project details
Scientific Abstract
We aim to investigate the composition of the gut virome as a marker for resistance against anti-TNF therapy in Crohn's disease patients. We will functionally characterize the interaction of identified viruses with mucosal CD14+ macrophages. In particular, we will analyze mechanisms of increased mucosal IL23R expression and IL-23 production that mediate molecular resistance to anti-TNF therapy in Crohn's disease, to finally elucidate a signaling pathway that determine non-response to therapy.
Involved:
Contributing FAU Organisations:
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
