J92: Microglial impact on neuronal connectivity in a mouse model of oligodendroglial synucleinopathy
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2021
End date : 31.12.2021
Project details
Scientific Abstract
Multiple system atrophy (MSA) is characterized by neurodegeneration and neuroinflammatory response of myeloid cells. The goal of this project is to decipher the role of microglia in disease mechanisms of MSA. Depletion of microglia results in improved survival, however, also in behavioural motor deficits in a MSA mouse model. Structural, biochemical and transcriptional approaches will be used to characterize changes in neuronal connectivity and synaptic networks upon microglia depletion in MSA.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Molecular Neurology
Medizinische Fakultät
