A088: Regulatory interaction btw. cyclins and cytomegalovirus kinase pUL97: focus on pUL97 drug resistance mutations
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2020
End date : 31.07.2022
Extension date: 31.07.2023
Project details
Scientific Abstract
HCMV replication is characterized by viral CDK-cyclin interaction. The CDK-like viral kinase pUL97 interacts with human cyclins. CycB1 is phosphorylated upon the interaction, dependent on pUL97 activity, whereas cycT1/H interaction stimulates pUL97 activity and substrate phosphorylation. Regions for cyclin interaction and antiviral drug resistance show overlaps in pUL97, so that this correlation will be elucidated in terms of viral fitness for the development of a novel antiviral strategy.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Klinische und Molekulare Virologie
Medizinische Fakultät
