P053: From serotonin receptor signaling to antigen presentation deciphering the molecular mechanism
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2019
End date : 31.03.2020
Project details
Scientific Abstract
Non-classical HLA class II molecule HLA-DO largely influences the presented peptide repertoire in HLA class II. HLA-DO expression was shown to play a role in type 1 diabetes, in the generation of neutralizing antibodies to viral infections and in immune responses after allogeneic stem cell transplantation. However, the regulation of HLA-DO is distinct from other class II molecules and remains elusive. We here hypothesize that serotonin receptor signaling plays a role in the regulation of HLA-DO.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 5 – Haematology and Oncology
Medizinische Fakultät
