Reaction kinetics of dual setting α-tricalcium phosphate cements
Hurle K, Christel T, Gbureck U, Moseke C, Neubauer J, Götz-Neunhoeffer F (2016)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2016
Journal
Publisher: Springer New York LLC
Book Volume: 27
Pages Range: 1-13
Article Number: 1
Journal Issue: 1
DOI: 10.1007/s10856-015-5616-y
Abstract
Addition of ductile polymers to calcium-deficient hydroxyapatite (CDHA)—forming bone cements based on α-tricalcium phosphate (α-TCP) is a promising approach to improve the mechanical performance of α-TCP cements and extend their application to load-bearing defects, which is else impeded by the brittleness of the hardened cement. One suitable polymer is poly-(2-hydroxyethylmethacrylate) (p-HEMA), which forms during cement setting by radical polymerisation of the monomer. In this study the hydration kinetics and the mechanical performance of α-TCP cements modified with addition of different HEMA concentrations (0–50 wt% in the cement liquid) was investigated by quantitative in situ XRD and four-point bending tests. Morphology of CDHA crystals was monitored by scanning electron microscopy. The hydration of α-TCP to CDHA was increasingly impeded and the visible crystal size of CDHA increasingly reduced with increasing HEMA concentration. Modification of the cements by adding 50 wt% HEMA to the cement liquid changed the brittle performance of the hardened cement to a pseudoplastic behaviour, reduced the flexural modulus and increased the work of fracture, while lower HEMA concentrations had no significant effect on these parameters. In such a composite, the extent of CDHA formation was considerably reduced (34.0 ± 1.8 wt% CDHA with 50 % HEMA compared to 54.1 ± 2.4 wt% CDHA in the reference formed after 48 h), while the general reaction kinetics were not changed. In conclusion, while the extent of CDHA formation was decreased, the mechanical properties were noticeably improved by addition of HEMA. Hence, α-TCP/HEMA composites might be suitable for application in some load-bearing defects and have adequate properties for mechanical treatment after implantation, like insertion of screws.
Authors with CRIS profile
Katrin Hurle
Lehrstuhl für Mineralogie
Jürgen Neubauer
Naturwissenschaftliche Fakultät
Friedlinde Götz-Neunhoeffer
Naturwissenschaftliche Fakultät
Involved external institutions
Germany (DE)How to cite
APA:
Hurle, K., Christel, T., Gbureck, U., Moseke, C., Neubauer, J., & Götz-Neunhoeffer, F. (2016). Reaction kinetics of dual setting α-tricalcium phosphate cements. Journal of Materials Science: Materials in Medicine, 27(1), 1-13. https://dx.doi.org/10.1007/s10856-015-5616-y
MLA:
Hurle, Katrin, et al. "Reaction kinetics of dual setting α-tricalcium phosphate cements." Journal of Materials Science: Materials in Medicine 27.1 (2016): 1-13.
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