Rai R, Tallawi M, Grigore A, Boccaccini AR (2012)
Publication Type: Journal article, Review article
Publication year: 2012
Publisher: Elsevier
Book Volume: 37
Pages Range: 1051-1078
Journal Issue: 8
DOI: 10.1016/j.progpolymsci.2012.02.001
Poly(glycerol sebacate) (PGS) is a biodegradable polymer increasingly used in a variety of biomedical applications. This polyester is prepared by polycondensation of glycerol and sebacic acid. PGS exhibits biocompatibility and biodegradability, both highly relevant properties in biomedical applications. PGS also involves cost effective production with the possibility of up scaling to industrial production. In addition, the mechanical properties and degradation kinetics of PGS can be tailored to match the requirements of intended applications by controlling curing time, curing temperature, reactants concentration and the degree of acrylation in acrylated PGS. Because of the flexible and elastomeric nature of PGS, its biomedical applications have mainly targeted soft tissue replacement and the engineering of soft tissues, such as cardiac muscle, blood, nerve, cartilage and retina. However, applications of PGS are being expanded to include drug delivery, tissue adhesive and hard tissue (i.e., bone) regeneration. The design and fabrication of PGS based devices for applications that mimic native physiological conditions are also being pursued. Novel designs range from accordion-like honeycomb structures for cardiac patches, gecko-like surfaces for tissue adhesives to PGS (nano) fibers for extra cellular matrix (ECM) like constructs; new design avenues are being investigated to meet the ever growing demand for replacement tissues and organs. In less than a decade PGS has become a material of great scrutiny and interest by the biomedical research community. In this review we consolidate the valuable existing knowledge in the fields of synthesis, properties and biomedical applications of PGS and PGS-related biomaterials and devices. © 2012 Elsevier Ltd.
APA:
Rai, R., Tallawi, M., Grigore, A., & Boccaccini, A.R. (2012). Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): A review. Progress in Polymer Science, 37(8), 1051-1078. https://doi.org/10.1016/j.progpolymsci.2012.02.001
MLA:
Rai, Ranjana, et al. "Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): A review." Progress in Polymer Science 37.8 (2012): 1051-1078.
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