Copper releasing boron containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering

Erol MM, Mournio V, Newby P, Chatzistavrou X, Roether J, Hupa L, Boccaccini AR (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Acta Biomaterialia Elsevier

Publisher: Elsevier

Book Volume: 8

Pages Range: 792-801

Journal Issue: 2

DOI: 10.1016/j.actbio.2011.10.013

Abstract

The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO 2, 15 CaO, 18.4 Na 2O, 0.1 MgO and 1.5 B 2O 3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration. © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universidad de Buenos Aires (UBA) / University of Buenos Aires AR Argentina (AR) Åbo Akademi University FI Finland (FI) Istanbul Technical University / İstanbul Teknik Üniversitesi (İTÜ) TR Turkey (TR) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB)

How to cite

APA:

Erol, M.M., Mournio, V., Newby, P., Chatzistavrou, X., Roether, J., Hupa, L., & Boccaccini, A.R. (2012). Copper releasing boron containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering. Acta Biomaterialia, 8(2), 792-801. https://dx.doi.org/10.1016/j.actbio.2011.10.013

MLA:

Erol, M. M., et al. "Copper releasing boron containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering." Acta Biomaterialia 8.2 (2012): 792-801.

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