The age and genomic integrity of neurons after cortical stroke in humans

Huttner HB, Bergmann O, Salehpour M, Racz A, Tatarishvili J, Lindgren E, Csonka T, Csiba L, Hortobagyi T, Mehes G, Englund E, Solnestam BW, Zdunek S, Scharenberg C, Strom L, Stahl P, Sigurgeirsson B, Dahl A, Schwab S, Possnert G, Bernard S, Kokaia Z, Lindvall O, Lundeberg J, Frisen J (2014)


Publication Type: Journal article

Publication year: 2014

Journal

Publisher: Nature Publishing Group

Book Volume: 17

Pages Range: 801-3

Journal Issue: 6

DOI: 10.1038/nn.3706

Abstract

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

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APA:

Huttner, H.B., Bergmann, O., Salehpour, M., Racz, A., Tatarishvili, J., Lindgren, E.,... Frisen, J. (2014). The age and genomic integrity of neurons after cortical stroke in humans. Nature Neuroscience, 17(6), 801-3. https://doi.org/10.1038/nn.3706

MLA:

Huttner, Hagen B., et al. "The age and genomic integrity of neurons after cortical stroke in humans." Nature Neuroscience 17.6 (2014): 801-3.

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