Serotonin transporter gene and stress reactivity in unipolar depression : Role of the HPA system as endophenotype of the SLC6A4 gene
Welper H, Aller A, Guttenthaler V, Hoefels S, Lennertz L, Pfeiffer U, Schwab S, Zobel A (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Springer-Medizin-Verl.
Book Volume: 85
Pages Range: 336-43
Journal Issue: 3
DOI: 10.1007/s00115-012-3702-7
Abstract
A length polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with both depression and hypothalamic-pituitary-adrenal (HPA) system activity. A dysregulation of the HPA system is considered to be a candidate endophenotype of depression. The objective of the present study was an investigation of a possible gene-endophenotype-interaction between 5-HTTLPR and HPA system activity in a sample of inpatients with major depression.A total of 237 inpatients with major depression were genotyped for 5-HTTLPR and participated in a combined dexamethasone-corticotropin-releasing hormone test (Dex-CRH test) as well as using the Hamilton score (Hamilton rating scale for depression) to determine the severity of the psychopathology.Patients with the ss-genotype showed a significantly higher HPA -system activity in comparison to patients with the lI-genotype, but no association between 5-HTTLPR and the severity of psychopathology could be detected.The results of the current study demonstrate an influence of 5-HTTLPR on dysregulation of the HPA system in patients with major depression and support the hypothesis that 5-HTTLPR- and HPA-system-interaction constitutes an important component in the pathogenesis of depression.
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APA:
Welper, H., Aller, A., Guttenthaler, V., Hoefels, S., Lennertz, L., Pfeiffer, U.,... Zobel, A. (2014). Serotonin transporter gene and stress reactivity in unipolar depression : Role of the HPA system as endophenotype of the SLC6A4 gene. Der Nervenarzt, 85(3), 336-43. https://doi.org/10.1007/s00115-012-3702-7
MLA:
Welper, H., et al. "Serotonin transporter gene and stress reactivity in unipolar depression : Role of the HPA system as endophenotype of the SLC6A4 gene." Der Nervenarzt 85.3 (2014): 336-43.
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